Publications

1.     Implementation and evaluation of Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) for the treatment of patients with malignant pleural effusion: study protocol for the Danish phase-I PITAC-OPC5 study. Hansen, Pernille Schjødt, Graversen, Martin, Detlefsen, Sönke, Ainsworth, Alan Patrick, Fristrup, Claus Wilki, Eckhoff, Lise, Jelin-Klaric, Mia and Mortensen, Michael Bau. Pleura and Peritoneum, 2024. https://doi.org/10.1515/pp-2024-0014 (in press)

2.     Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) directed therapy of patients with malignant pleural effusion and pleural metastasis. Hansen, Pernille Schjødt, Graversen, Martin, Detlefsen, Sönke, Ainsworth, Alan Patrick and Mortensen, Michael Bau. Pleura and Peritoneum, 2024. https://doi.org/10.1515/pp-2024-0008 (in press)

3.     Impact of laparoscopic ultrasound during PIPAC directed treatment of unresectable peritoneal metastasis. Jørgensen MS, Ainsworth AP, Fristrup CW, Mortensen MB, Graversen M. Pleura Peritoneum. 2024 Sep 6;9(3):107-112. doi: 10.1515/pp-2024-0007. PMID: 39544431; PMCID: PMC11558172.

4.     Outcome of patients with peritoneal metastasis from ovarian cancer treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Foslund IT, von Magius SAV, Ainsworth AP, Detlefsen S, Fristrup CW, Knudsen AO, Mortensen MB, Tarpgaard LS, Jochumsen KM, Graversen M. Pleura Peritoneum. 2024 Jun 10;9(2):69-77. doi: 10.1515/pp-2023-0049. PMID: 38948328; PMCID: PMC11211650.

5.     RNA expression profiling of peritoneal metastasis from pancreatic cancer treated with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC). Detlefsen S, Burton M, Ainsworth AP, Fristrup C, Graversen M, Pfeiffer P, Tarpgaard LS, Mortensen MB. Pleura Peritoneum. 2024 Jun 3;9(2):79-91. doi: 10.1515/pp-2024-0001. PMID: 38948326; PMCID: PMC11211652.

6.     Standardizing eligibility and patient selection for Pressurized Intraperitoneal Aerosol Chemotherapy: A Delphi consensus statement. Tozzi F, Rashidian N, Ceelen W, Callebout E, Hübner M, Sgarbura O, Willaert W; INPACT study group. Eur J Surg Oncol. 2024 Jun;50(6):108346. doi: 10.1016/j.ejso.2024.108346. Epub 2024 Apr 18. PMID: 38669779.

7.     Review on treatment of pleural metastasis and malignant pleural effusion with Pressurized IntraThoracic Aerosol Chemotherapy (PITAC). Hansen PS, Graversen M, Detlefsen S, Mortensen MB. Pleura Peritoneum. 2024 May 17;9(2):47-53. doi: 10.1515/pp-2023-0048. PMID: 38948327; PMCID: PMC11211649.

8.     Second annual report from the ISSPP PIPAC database. Mortensen MB, Casella F, Düzgün Ö, Glehen O, Hewett P, Hübner M, Jørgensen MS, Königsrainer A, Marin M, Pocard M, Rezniczek G, So J, Fristrup CW. Pleura Peritoneum. 2023 Dec 13;8(4):141-146. doi: 10.1515/pp-2023-0047. eCollection 2023 Dec. PMID: 38144218

9.     What is long-term survival in patients with peritoneal metastasis from gastric, pancreatic, or colorectal cancer? A study of patients treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC). Kryh-Jensen CG, Fristrup CW, Ainsworth AP, Detlefsen S, Mortensen MB, Pfeiffer P, Tarpgaard LS, Graversen M. Pleura Peritoneum. 2023 Dec 14;8(4):147-155. doi: 10.1515/pp-2023-0038. eCollection 2023 Dec. PMID: 38144215

10.  Feasibility and Safety of Laparoscopic D2 Gastrectomy in Combination with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Gastric Cancer at High Risk of Recurrence-The PIPAC-OPC4 Study. Graversen M, Rouvelas I, Ainsworth AP, Bjarnesen AP, Detlefsen S, Ellebaek SB, Fristrup CW, Liljefors MG, Lundell L, Nilsson M, Pfeiffer P, Tarpgaard LS, Tsekrekos A, Mortensen MB. Ann Surg Oncol. 2023 Jul;30(7):4433-4441. doi: 10.1245/s10434-023-13278-w. Epub 2023 Mar 3. PMID: 36867174

11.  Response Evaluation in Patients with Peritoneal Metastasis Treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Roensholdt S, Detlefsen S, Mortensen MB, Graversen M. J Clin Med. 2023 Feb 6;12(4):1289. doi: 10.3390/jcm12041289. PMID: 36835824

12.  Treatment of Peritoneal Metastasis with Pressurized Intraperitoneal Aerosol Chemotherapy: Results from the Prospective PIPAC-OPC2 Study. Graversen M, Detlefsen S, Ainsworth AP, Fristrup CW, Knudsen AO, Pfeiffer P, Tarpgaard LS, Mortensen MB. Ann Surg Oncol. 2023 May;30(5):2634-2644. doi: 10.1245/s10434-022-13010-0. Epub 2023 Jan 5. PMID: 36602663

13.  The Implementation of a PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy) Program in Portugal. Bouça-Machado T, Aral M, Meireles S, Graversen M, Barbosa E. Acta Med Port. 2022 Dec 2;35(12):927-928. doi: 10.20344/amp.18834. Epub 2022 Nov 4. PMID: 36334077

14.  Importance of biopsy site selection for peritoneal regression grading score (PRGS) in peritoneal metastasis treated with repeated pressurized intraperitoneal aerosol chemotherapy (PIPAC). Fallah M, Detlefsen S, Ainsworth AP, Fristrup CW, Mortensen MB, Pfeiffer P, Tarpgaard LS, Graversen M. Pleura Peritoneum. 2022 May 30;7(3):143-148. doi: 10.1515/pp-2022-0108. eCollection 2022 Sep. PMID: 36159216

15.  Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases. Ceelen W, Sandra L, de Sande LV, Graversen M, Mortensen MB, Vermeulen A, Gasthuys E, Reynders D, Cosyns S, Hoorens A, Willaert W. EBioMedicine. 2022 Aug;82:104151. doi: 10.1016/j.ebiom.2022.104151. Epub 2022 Jul 15. PMID: 35843174

16.   Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC). Sgarbura O, Eveno C, Alyami M, Bakrin N, Guiral DC, Ceelen W, Delgadillo X, Dellinger T, Di Giorgio A, Kefleyesus A, Khomiakov V, Mortensen MB, Murphy J, Pocard M, Reymond M, Robella M, Rovers KP, So J, Somashekhar SP, Tempfer C, Van der Speeten K, Villeneuve L, Yong WP, Hübner M. Pleura Peritoneum. 2022 Mar 1;7(1):1-7. doi: 10.1515/pp-2022-0102. eCollection 2022 Mar 1. PMID: 35602919.

17.  Role of immunohistochemistry for interobserver agreement of Peritoneal Regression Grading Score in peritoneal metastasis. Detlefsen S, Windedal T, Bibeau F, Bruhn LV, Carr N, Graversen M, Markowski K, Mortensen MB, Neureiter D, Sempoux C, Solass W, Thinesen MT, Fristrup C. Hum Pathol. 2022 Feb;120:77-87. doi: 10.1016/j.humpath.2021.12.005. Epub 2021 Dec 24. PMID: 34954136

18.  The ISSPP PIPAC database: design, process, access, and first interim analysis. Mortensen MB, Glehen O, Horvath P, Hübner M, Hyung-Ho K, Königsrainer A, Pocard M, Reymond MA, So J, Fristrup CW. Pleura Peritoneum. 2021 Apr 22;6(3):91-97. doi: 10.1515/pp-2021-0108. eCollection 2021 Sep. PMID: 34676282

19.  Local peritoneal toxicity from adjuvant pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in high-risk patients with colonic cancer. Graversen M, Detlefsen S, Pfeiffer P, B Mortensen M. Br J Surg. 2021 May 27;108(5):e187-e188. doi: 10.1093/bjs/znab043. PMID: 33793765

20.  Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)-directed treatment of peritoneal metastasis in end-stage colo-rectal cancer patients. Ellebæk SB, Graversen M, Detlefsen S, Lundell L, Fristrup CW, Pfeiffer P, Mortensen MB. Pleura Peritoneum. 2020 May 15;5(2):20200109. doi: 10.1515/pp-2020-0109. eCollection 2020 Jun 1. PMID: 32566727

21.  Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles: Proof of Concept and Preclinical Validation. Van de Sande L, Rahimi-Gorji M, Giordano S, Davoli E, Matteo C, Detlefsen S, D'Herde K, Braet H, Shariati M, Remaut K, Xie F, Debbaut C, Ghorbaniasl G, Cosyns S, Willaert W, Ceelen W. Adv Healthc Mater. 2020 Aug;9(16):e2000655. doi: 10.1002/adhm.202000655. Epub 2020 Jun 16. PMID: 32548967

22.  Next-generation sequencing and histological response assessment in peritoneal metastasis from pancreatic cancer treated with PIPAC. Nielsen M, Graversen M, Ellebæk SB, Kristensen TK, Fristrup C, Pfeiffer P, Mortensen MB, Detlefsen S. J Clin Pathol. 2021 Jan;74(1):19-24. doi: 10.1136/jclinpath-2020-206607. Epub 2020 May 8. PMID: 32385139

23.  Bidirectional treatment of peritoneal metastasis with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) and systemic chemotherapy: a systematic review. Ploug M, Graversen M, Pfeiffer P, Mortensen MB. BMC Cancer. 2020 Feb 10;20(1):105. doi: 10.1186/s12885-020-6572-6. PMID: 32041558

24.  Pressurized intraperitoneal aerosol chemotherapy (PIPAC) of peritoneal metastasis from gastric cancer: a descriptive cohort study. Ellebæk SB, Graversen M, Detlefsen S, Lundell L, Fristrup CW, Pfeiffer P, Mortensen MB. Clin Exp Metastasis. 2020 Apr;37(2):325-332. doi: 10.1007/s10585-020-10023-5. Epub 2020 Jan 30. PMID: 32002724

25.  [Pressurised intraperitoneal aerosol chemotherapy (PIPAC) for the treatment of peritoneal metastases]. Graversen M, Detlefsen S, Knudsen AØ, Pfeiffer P, Mortensen MB. Ugeskr Laeger. 2019 Oct 14;181(20A):V04190224. PMID: 31610840

26.  Pressurized IntraPeritoneal Aerosol Chemotherapy with one minute of electrostatic precipitation (ePIPAC) is feasible, but the histological tumor response in peritoneal metastasis is insufficient. Graversen M, Detlefsen S, Ellebaek SB, Fristrup C, Pfeiffer P, Mortensen MB. Eur J Surg Oncol. 2020 Jan;46(1):155-159. doi: 10.1016/j.ejso.2019.08.024. Epub 2019 Aug 29. PMID: 31493986

27.  Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) as an outpatient procedure. Graversen M, Lundell L, Fristrup C, Pfeiffer P, Mortensen MB. Pleura Peritoneum. 2018 Nov 27;3(4):20180128. doi: 10.1515/pp-2018-0128. eCollection 2018 Dec 1. PMID: 30911669

28.  Intraperitoneal aerosolization of albumin-stabilized paclitaxel nanoparticles (Abraxane™) for peritoneal carcinomatosis - a phase I first-in-human study. Van De Sande L, Graversen M, Hubner M, Pocard M, Reymond M, Vaira M, Cosyns S, Willaert W, Ceelen W. Pleura Peritoneum. 2018 Jun 8;3(2):20180112. doi: 10.1515/pp-2018-0112. eCollection 2018 Jun 1. PMID: 30911657

29.  Treatment of peritoneal carcinomatosis with Pressurized IntraPeritoneal Aerosol Chemotherapy - PIPAC-OPC2. Graversen M, Detlefsen S, Asmussen J, Mahdi B, Fristrup C, Pfeiffer P, Mortensen MB. Pleura Peritoneum. 2018 Jun 9;3(2):20180108. doi: 10.1515/pp-2018-0108. eCollection 2018 Jun 1. PMID: 30911656

30.  Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in resected high-risk colon cancer patients - study protocol for the PIPAC-OPC3 Trial. A prospective, controlled phase 2 Study. Graversen M, Detlefsen S, Fristrup C, Pfeiffer P, Mortensen MB. Pleura Peritoneum. 2018 Jun 12;3(2):20180107. doi: 10.1515/pp-2018-0107. eCollection 2018 Jun 1. PMID: 30911655

31.  Detection of free intraperitoneal tumour cells in peritoneal lavage fluid from patients with peritoneal metastasis before and after treatment with pressurised intraperitoneal aerosol chemotherapy (PIPAC). Graversen M, Fristrup C, Kristensen TK, Larsen TR, Pfeiffer P, Mortensen MB, Detlefsen S. J Clin Pathol. 2019 May;72(5):368-372. doi: 10.1136/jclinpath-2018-205683. Epub 2019 Feb 12. PMID: 30755498

32.  Reproducibility of the peritoneal regression grading score for assessment of response to therapy in peritoneal metastasis. Solass W, Sempoux C, Carr NJ, Bibeau F, Neureiter D, Jäger T, Di Caterino T, Brunel C, Klieser E, Fristrup CW, Mortensen MB, Detlefsen S. Histopathology. 2019 Jun;74(7):1014-1024. doi: 10.1111/his.13829. Epub 2019 Apr 14. PMID: 30687944

33.  Prospective, single-center implementation and response evaluation of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal metastasis. Graversen M, Detlefsen S, Bjerregaard JK, Fristrup CW, Pfeiffer P, Mortensen MB. Ther Adv Med Oncol. 2018 Jun 1;10:1758835918777036. doi: 10.1177/1758835918777036. eCollection 2018. PMID: 29899763

34.  Severe peritoneal sclerosis after repeated pressurized intraperitoneal aerosol chemotherapy with oxaliplatin (PIPAC OX): report of two cases and literature survey. Graversen M, Detlefsen S, Pfeiffer P, Lundell L, Mortensen MB. Clin Exp Metastasis. 2018 Mar;35(3):103-108. doi: 10.1007/s10585-018-9895-9. Epub 2018 Apr 28. PMID: 29705882

35.  Peritoneal metastasis from pancreatic cancer treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Graversen M, Detlefsen S, Bjerregaard JK, Pfeiffer P, Mortensen MB. Clin Exp Metastasis. 2017 Jun;34(5):309-314. doi: 10.1007/s10585-017-9849-7. Epub 2017 May 17. PMID: 28516306

36.  Environmental safety during the administration of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Graversen M, Pedersen PB, Mortensen MB. Pleura Peritoneum. 2016 Dec 1;1(4):203-208. doi: 10.1515/pp-2016-0019. Epub 2016 Nov 25. PMID: 30911624

37.  Peritoneal sampling and histological assessment of therapeutic response in peritoneal metastasis: proposal of the Peritoneal Regression Grading Score (PRGS). Solass W, Sempoux C, Detlefsen S, Carr NJ, Bibeau F. Pleura Peritoneum. 2016 Jun 1;1(2):99-107. doi: 10.1515/pp-2016-0011. Epub 2016 Jun 7. PMID: 30911613

38.  [Treatment of peritoneal carcinomatosis with pressurized intraperitoneal aerosol chemotherapy]. Graversen M, Pfeiffer P, Mortensen MB. Ugeskr Laeger. 2016 May 23;178(21):V11150928. PMID: 27237925

39.  Fjællegaard K, Petersen JK, Armbruster K, Jensen HK, Skaarup SH, Laursen CB, Clementsen PF, Bødtger U. [Malignant pleural effusion]. Ugeskr Laeger. 2021 Apr 26;183(17):V10200751. Danish. PMID: 33913425.

40.  Alwakeel AJ, Shieh B, Beaudoin S. Management of Malignant Pleural Effusions-The Effusion Strikes Back: A Teachable Moment. JAMA Intern Med. 2022 Feb 1;182(2):218-219. doi: 10.1001/jamainternmed.2021.6775. PMID: 34928296.

41.  Gonnelli F, Hassan W, Bonifazi M, Pinelli V, Bedawi EO, Porcel JM, Rahman NM, Mei F. Malignant pleural effusion: current understanding and therapeutic approach. Respir Res. 2024 Jan 19;25(1):47. doi: 10.1186/s12931-024-02684-7. PMID: 38243259; PMCID: PMC10797757.

42.  Wong T, Fuld AD, Feller-Kopman DJ. Malignant Pleural Effusions in the Era of Immunotherapy and Antiangiogenic Therapy. Semin Respir Crit Care Med. 2023 Aug;44(4):447-453. doi: 10.1055/s-0043-1769092. Epub 2023 Jun 12. PMID: 37308114.

PhD projects

• Implementation and response evaluation of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for peritoneal metastasis in Denmark. Graversen M. Defended February 10th, 2020, Faculty of Health Sciences, University of Southern Denmark
• New methods for patient selection and response assessment during Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) directed treatment. Signe Rønsholdt. Faculty of Health Sciences, University of Southern Denmark, 2023-25 (ongoing).