PIPAC Trials

Clinical trials

• Completed studies
  
  

PIPAC-OPC1

ClinicalTrials.gov ID NCT02320448

A single-center clinical trial on the implementation, feasibility and response evaluation of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).

 

PIPAC-OPC2

ClinicalTrials.gov ID NCT03287375

A single-center prospectively controlled phase-II, one-arm, open-labeled clinical trial investigating the treatment effect of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).

Trial amendment:

Amendment to the PIPAC-OPC2 study investigating the feasibility and tumor response to electrostatic Pressurized IntraPeritoneal Aerosol Chemotherapy (ePIPAC).

 

PIPAC-OPC3

ClinicalTrials.gov ID NCT03280511

A single-center prospectively controlled non-randomized, non-blinded phase-II cohort study investigating the use of adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in high-risk colon cancer patients.

 

PIPAC-OPC4

ClinicalTrials.gov ID NCT04047004

A prospectively controlled bi-institutional trial investigating the feasibility of adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in combination with laparoscopic gastrectomy in patients with gastric adenocarcinoma at high-risk of recurrence.

 

• Ongoing studies

PITAC-OPC5

ClinicalTrials.gov ID NCT06421610

A single center clinical trial on the implementation and feasibility of Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in patients with malign pleural effusion.

 

PIPAC-OPC7

ClinicalTrials.gov ID NCT06144853

A pilot study on the feasibility of repeated FDG-PET/CT-scans as a method of patient selection and response evaluation in patients treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).

 

 

• ·Future studies

PIPAC-OPC6 (EPICURE)

ClinicalTrials.gov ID NCT06295094

An international multicenter randomized controlled trial investigating the efficacy of PIPAC and minimal invasive radical resection in high-risk gastric cancer patients.

 

PIPAC-OPC8

A single center clinical trial on the implementation and feasibility of Paclitaxel in PIPAC directed therapy.

 

Register-based research

• Ongoing research

The ISSPP-PIPAC Database

Designing an international multicenter PIPAC database under the auspices of The International Society for the Study of Pleura and Peritoneum (ISSPP).

 

Post-PIPAC

A register study based on the Danish ISSPP-PIPAC cohort with data enrichment from several unique Danish Health and Demographic Registers.

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